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Featured Review: Does behavioural support help people to stop smoking?

Thu, 12/31/2020 - 16:48
Behavioural interventions for smoking cessation: an overview and network meta‐analysis

Key messages 

Behavioural support can help more people to stop smoking for six months or longer, without causing unwanted effects.

Some types of support appear to work better than others. More studies are needed to identify the best ways to support people who are trying to stop smoking, and to identify the best people to support them.

Stopping smoking

The best thing people who smoke can do for their health is to stop smoking. People breathe more easily and cough less when they stop smoking. Stopping also lowers their risk of getting lung cancer and other diseases.

How to help people stop smoking

Most people who smoke want to stop, but many find it difficult. People who smoke may use nicotine replacement therapy, such as nicotine patches or gum, or other medicines to help them stop. Behavioural support provides an alternative – or additional – way to help people stop smoking. Sometimes behavioural support can be combined with nicotine replacement or other medicines to help people stop smoking.

Types of behavioural support can include: advice and counselling on ways to make it easier to stop smoking; information about why or how to stop; or a combination. Behavioural support can be given in group sessions or one-to-one.

Why did the authors do this Cochrane Review?

The authors wanted to find out:

  • which types of behavioural support work best to help people stop smoking;
  • the best ways to give behavioural support (including the best people to give it); and
  • what aspects of behavioural support help someone to stop smoking.

They also wanted to know if behavioural support can cause any unwanted effects.

What did authors do?

They searched for Cochrane Reviews of behavioural support to stop smoking, to identify relevant studies of adults who smoked. They then compared the studies with each other, to find out how well the different types of behavioural support helped people to stop smoking.

Search date: the authors included evidence published up to July 2020.

What they found

The authors found 33 Cochrane Reviews, from which they identified 312 relevant studies in 250,503 adults (aged 18 to 63 years) who smoked cigarettes. The studies investigated 437 different combinations of ways to stop smoking.

The studies looked at the following types of behavioural support, among others:

  • giving someone information about their test results, or their risk of smoking-related disease;
  • counselling (face-to-face, by telephone or by video call);
  • self-help materials, resources, and reminders by mobile phone messages or apps;
  • rewards (money, or a chance to win money by entering competitions);
  • exercise-based support; and
  • hypnotherapy.

In the studies, a variety of people provided behavioural support, including: doctors, consultants, nurses, pharmacists, dentists, counsellors and lay health advisors.

Most studies were conducted in the USA or Western Europe; 115 studies took place in healthcare settings and 195 took place in the community. On average, people taking part in the studies were followed up for 10.5 months.

The studies compared the effects of behavioural support with:

  • no behavioural support;
  • usual or standard care;
  • less-intense forms of the behavioural support; or other approaches.

The authors compared all treatments with each other using a mathematical method called network meta-analysis.

What are the main results of this review?

Compared with no behavioural support it was clear that some types of behavioural support increased people's chances of quitting for six months or longer, including: counselling and giving them money for successfully stopping smoking. More people stopped smoking with these types of support whether or not they were also taking medicines to help them stop smoking.

Behavioural support by text messages probably helped more people to stop smoking than no support.

Compared with no support, tailoring behavioural support to the person, or group of people, trying to stop smoking probably slightly increased how many of them stopped smoking, as did support that focused on how to stop smoking.

Increasing the intensity of the support given, such as contacting people more often or having longer sessions, modestly increased how many people stopped smoking.

The authors are uncertain about:

  •  the effects of other types of behavioural support, including hypnotherapy, exercise-based support, and entering competitions; and
  • the effect of who gives the behavioural support.

Only some studies reported results for unwanted effects; in these, behavioural support did not increase the numbers of any unwanted effects.

How confident are the authors in these results?

The authors are confident that counselling and rewards of money help people to stop smoking; they do not expect that more evidence will change these results. They are less confident in the results for other types of behavioural support, and about who gives the support and how. They found limitations with some of the studies, including how they were designed, conducted, and reported. These results are likely to change when more evidence becomes available. More studies are needed.

Tuesday, January 5, 2021

Cochrane Sweden collaborates on trial transparency report

Tue, 12/22/2020 - 15:17

Cochrane Sweden, in collaboration with TranspariMED, recently published a report on clinical trial transparency in Sweden.

The report draws on data from the EU Trials Tracker and summarises the current extent of clinical drug trial reporting for different organisations in Sweden. Under the European Commission’s Clinical Trial Regulation, clinical trial sponsors must post summary results to the EU Clinical Trials Register within one year of a study ending, or six months for paediatric trials.

The report found that over 70% of clinical trials whose results were verifiably due had not yet posted results. This is far below the European average. However, several Swedish trial sponsors have already pledged to make improvements.

Matteo Bruschettini, Director of Cochrane Sweden, says of the report: “Cochrane Sweden, which was awarded full independent Cochrane centre status in 2020, promotes initiatives to improve the reporting of all studies. Our hope is that this report and the linked implications and recommendations can help to facilitate improved reporting of clinical trials within Sweden. We share the goal to get more complete and accurate evidence on which to make informed health decisions within healthcare, and better health for everyone.”

Cochrane supports clinical trial transparency. We rely on the availability of results from clinical trials to produce high quality and relevant systematic reviews. When trial results – whether positive, negative, or neutral – are not published, it is not possible to make truly evidence-informed decisions about healthcare, and people can be put at risk of harm.

Tuesday, December 29, 2020

What are the most effective interventions during pregnancy for preventing stillbirth?

Mon, 12/21/2020 - 15:35

Antenatal interventions for preventing stillbirth, fetal loss and perinatal death: an overview of Cochrane systematic reviews

A stillbirth is generally defined as the death of a baby before birth, at or after 24 weeks of development. It is most common in low‐ and middle‐income countries but also affects people in high‐income countries. Numbers of stillbirths have not fallen much in the last 20 years and, despite the high numbers, it is not widely recognised as a global health problem.

This overview of Cochrane systematic reviews included 43 Cochrane reviews that assessed 61 different ways of preventing stillbirth during pregnancy, or infant deaths around the time of birth. However, few of these provided any clear evidence of an effect during pregnancy to reduce the risk of stillbirth or infant death. They were grouped into four different areas: nutrition, preventing infection, managing mothers' other healthcare problems, and looking after the baby before it is born.

Nutrition

  • Giving mothers balanced energy and protein supplements to increase the growth of the baby, particularly in undernourished pregnant women, probably reduces stillbirth by 40%.
  • For Vitamin A alone versus placebo (sham) or no treatment, and multiple micronutrients with iron and folic acid compared with iron with or without folic acid, there was clear evidence of no effect.

Prevention and management of infections

  • Insecticide‐treated anti‐malarial nets versus no nets may reduce loss of the baby in the womb (fetus) by 33%.

Prevention, detection and management of other healthcare problems

  • Where midwives were the primary healthcare provider, particularly for low‐risk pregnant women, loss of the fetus or infant deaths fell by 16%.
  • Having a trained traditional birth attendant versus having an untrained traditional birth attendant probably reduces stillbirth in rural populations of low‐ and middle‐income countries by 31% and infant death by 30%.
  • A reduced number of antenatal care visits probably results in an increase in infant death around the time of birth.
  • Community‐based intervention packages (including community‐support groups/women's groups, community mobilisation and home visits, or training traditional birth attendants who made home visits) may reduce stillbirth by 19%.

Checking the baby before birth

  • Cardiotocography measures the baby's heart rate and contractions in the womb. It can be recorded automatically by computer or manually, with pen and paper. Computerised cardiotocography to monitor baby’s well‐being in the womb, by measuring contractions, probably reduces the rate of infant deaths around the time of birth by 80% when compared with traditional cardiotocography.

The overview was uncertain about the effects of other methods.

Further high‐quality RCTs are needed to evaluate the effects of antenatal preventive interventions and which approaches are most effective to reduce the risk of stillbirth. Stillbirth (or fetal death), perinatal and neonatal death need to be reported separately in future RCTs of antenatal interventions to allow assessment of different interventions on these rare but important outcomes and they need to clearly define the target populations of women where the intervention is most likely to be of benefit.

Dr. Erika Ota, lead author and professor at the St. Luke’s International University in Japan says, “Stillbirth can be very upsetting for families and looking at what the evidence was across Cochrane systematic reviews was important to us. Cochrane systematic reviews provide high quality evidence. We assessed 43 Cochrane reviews with over 60 different ways to prevent stillbirth and infant deaths at birth.

We found that from these 60 different interventions, most interventions were unable to demonstrate a clear effect in reducing stillbirth or perinatal death. However, several interventions suggested a clear benefit to preventing still birth and infant deaths at birth, such as balanced energy/protein supplements, midwife‐led models of care, training versus not training traditional birth attendants, and antenatal cardiotocography. Possible benefits were also observed for insecticide‐treated anti‐malarial nets and community‐based intervention packages, whereas a reduced number of antenatal care visits were shown to be harmful.

The effectiveness of the methods used to prevent stillbirth varied depending on where they took place, highlighting that it is important to understand how they were tested. Unfortunately the findings cannot be applied to women in general and across all global settings but hope this overview will help show that further high-quality trials are needed in low- and middle income countries where a high burden of stillbirths occur.”

Wednesday, December 23, 2020

Cochrane Mexico vs COVID-19: Evidence to guide paediatric COVID-19 patient care

Mon, 12/21/2020 - 14:50

The first COVID-19 case in Mexico was announced on 28 February 2020, with an anticipation that the number of cases would rapidly increase, some cases even occurring in children. To address this need, Cochrane Mexico worked with paediatric infectious disease specialists to create a Guide for COVID-19 diagnosis and treatment in paediatric patients. The Guide is for physicians in emergency departments, family physicians, paediatricians, and physicians working on newly created COVID-19 dedicated teams.

To create this guide, Cochrane Mexico reviewed all available literature on the characteristics of the virus, the mechanisms of transmission, clinical presentation and initial treatment recommendations. They finished reviewing the literature and developing the Guide as quickly as possible, so that it was available by the time the first cases in children began to appear.

Learn more about this guide and how Cochrane Mexico adapted to the changing situation and availability of evidence in this short case study. 

Monday, December 21, 2020

Special healthy ageing issue of Cochrane Library app released, as WHO launches Decade for Healthy Ageing Baseline Report

Thu, 12/17/2020 - 14:40

2021-2030 was recently formally declared as the UN Decade of Healthy Ageing at the UN General Assembly. The Decade of Healthy Ageing aims to bring together governments, civil society, international agencies, professionals, academia, the media, and the private sector to jointly take action in order to improve the lives of older people, their families, and the communities in which they live.

The Cochrane-Campbell Global Ageing Partnership has been working with the World Health Organization (WHO) since 2015, and has actively supported preparations for the Decade. This includes co-authoring the WHO Decade of Healthy Ageing Baseline Report, which sets the stage for the Decade. The report was published today, 17 December, and references 13 Cochrane Reviews. Prof Tracey Howe, Director of the Cochrane Campbell Global Ageing Partnership, attended and spoke at the launch, alongside WHO leadership, policymakers and civil society representatives from around the world.

Special issue of the Cochrane Library App

To tie in with the launch of the WHO Decade of Healthy Ageing Baseline Report, we have also launched a healthy ageing-focused issue of the Cochrane Library App.

The Cochrane Library app presents the latest up-to-date evidence from the Cochrane Library in a convenient, easy to navigate format which provides you with relevant, accessible research, when you need it, from the world’s leading experts in evidence-informed health care.

All content is free and new issues will download regularly.

Related

 

Thursday, December 17, 2020

Author Interview: Conflicts of interest in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews: associations with recommendations

Wed, 12/16/2020 - 20:42

In this short interview, PhD student Camilla Hansen Nejstgaard,  from Cochrane Denmark and Centre for Evidence-Based Medicine Odense (CEBMO) at the University of Southern Denmark, tells us about how conflicts of interest may impact on recommendations of drugs and medical devices. She is the lead author of a recently published Cochrane Methodology Review on this topic. 

What does this Cochrane review tell us about the impact of conflicts of interests in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews?

The findings from our review indicate that financial conflicts of interest are associated with favourable recommendations in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews. As an example, this means that guidelines written by authors with financial conflicts of interest, more often have recommendations that are favourable towards a new drug treatment than guidelines written by authors without conflicts of interest. We included 21 studies in our review and conducted four separate analyses on each of the four types of documents. These analyses provided similar findings but had some statistical uncertainty around the size of the effect .

We also investigated the impact of non-financial conflicts of interest. Such interest can occur, for example, when radiologists are authors of clinical guidelines on mammography screening (this is what we call specialty interests). However, we only found a single study investigating the impact from specialty interest in clinical guidelines and the results were uncertain, but indicated a similar direction of effect. 

Our findings are in line with previous Cochrane Reviews on conflicts of interest in primary research and systematic reviews. However, the results of our current review have less statistical precision and more research is needed, particularly on the impact of non-financial conflicts of interest.

What can guideline issuing organisations learn from this evidence?

Our findings suggest that authors of clinical guidelines may interpret evidence differently depending on whether or not they have financial conflicts of interest. Some guideline issuing organisations such as the National Institute for Health and Care Excellence, the US Preventive Services Task Force, and the World Health Organization have already implemented policies aimed at minimizing the potential impact from conflicts of interest. For example, by minimizing the number and role of guideline authors with financial conflicts of interest. Even though our review did not investigate the impact from such conflicts of interest policies, our findings support the practice of minimising conflicts of interest.

What should patients, doctors and healthcare decision makers take from this evidence?

Based on our findings, we suggest that patients, doctors, and healthcare decision makers primarily use clinical guidelines, opinion pieces, and narrative reviews that have been written by authors without financial conflicts of interest. If that is not possible, users should read and interpret the publications with caution. Furthermore, our findings suggest that if committee members, for example at a regulatory drug agency, are asked to vote on the recommendation of a drug approval, they may be more likely to vote in favour of approving the drug when they have financial conflicts of interest.

Why is this review important?

Recommendations in clinical guidelines, opinion pieces, and narrative reviews as well as decisions about which interventions are approved by advisory committees have substantial impact on the interventions offered to patients. It is therefore essential that such recommendations are evidence-based and as little influenced by conflicts of interest as possible. If not, we may end up wasting resources on treatments that do not actually work, or even harming patients.

Tuesday, January 5, 2021

Cochrane ENT seeks part-time Systematic Reviewer - Oxford, UK

Wed, 12/16/2020 - 18:18

Closing date: 7 January 2021 
Location: Oxford, UK

Cochrane ENT is looking for an experienced Systematic Reviewer to work with the Cochrane ENT team, based at Cochrane UK in Oxford. The main purpose of the role is to assist in the prioritisation of ENT topics and facilitate the completion of high-priority systematic reviews. The post-holder will also support the Cochrane ENT editorial team and authors with methodological advice.

Main duties of the post will include: leading scoping reviews to prioritise reviews in key ENT topic areas and devising template protocols, including core outcome measures; co-authoring Cochrane ENT protocols and reviews, usually as lead author; commenting editorially as a methods adviser on draft protocols and reviews.

You will have a MSc in a relevant area or a higher degree, plus a first degree in a health-related discipline or equivalent experience. You will have experience in conducting high-quality systematic reviews, including familiarity with Cochrane guidance and standards for the design, conduct and reporting of systematic reviews (e.g. MECIR and GRADE). Completion of at least one Cochrane review or systematic review for a guideline producer is desirable.

This part-time post is available immediately and is fixed-term for 12 months in the first instance. The part-time hours are 40% FTE (2 days per week) and we are also willing to discuss remote working options.

 

Wednesday, December 16, 2020 Category: Jobs

Cochrane Germany vs. COVID-19: Working together to share research evidence

Wed, 12/16/2020 - 16:08

During the COVID-19 pandemic, Cochrane Germany wanted to build partnerships to share the best available evidence with as many people as possible, and make the findings from Cochrane systematic reviews accessible to German-speaking audiences.

Cochrane achieved their goals in several ways.  They highlighted evidence and resources on their website and developed COVID-19 related blogs in partnership with Cochrane Switzerland and Cochrane Austria. They disseminated COVID-19 press releases to journalists, and partnered with the associated Institute of Evidence in Medicine (IfEM) at the Medical Center - University of Freiburg to create and coordinate a pool of pre-assessed studies and to produce continuously updated ‘living’ evidence syntheses and guidelines.

Read more about the success of Cochrane Germany during the COVID-109 pandemic in this short case story.

Friday, December 18, 2020

Featured Review: Drugs for correcting the basic defect in the most common cystic fibrosis-causing gene variant

Wed, 12/16/2020 - 11:24

Read this recently published Cochrane review about CFTR correctors, a therapy for cystic fibrosis targeted at specific variants (most commonly F508del)

In this review, the authors looked at drugs (or drug combinations) for correcting the basic defect in the most common cystic fibrosis (CF)-causing gene variant (F508del) and assessed their impact on outcomes important to people with Cystic Fibrosis, e.g. survival, quality of life (QoL), lung function and safety.

Professor Kevin Southern, lead author of this review, has been involved in the care of children with CF for over 30 years, and has a deep appreciation of the impact of this condition on the young people and their families. "It has been great to work with the team to produce this comprehensive review, which clearly identifies the positive impact that triple therapy has on the well being of people with CF. The benefits identified in trials will prove to be transformational for young adults with CF like Freya Miao (pictured here with her glass of milk to take this therapy), who can now focus on maintaining good health as they move through adult life."

He continued, "The review concludes that people with CF with one or two F508del gene variants will benefit from this intervention.  In some countries, people with this gene variant are not able to access this important new therapy because of both funding and regulatory issues, and this represents a significant inequality that needs to be addressed.”

Background

The CF gene makes a protein that helps salts move across cells in many parts of the body; over 80% of people with Cystic Fibrosis have at least one copy of F508del, meaning they make a full length of this protein, but it can not move through the cell correctly. Laboratory experiments suggest that if this protein reaches the cell wall, it may be able to function, restore salt movement, and correct the chronic problems that people with Cystic Fibrosis experience. The authors examined several agents for correcting F508del. Their original review showed that while single drugs alone were not effective, they were when combined with other drugs. This updated review includes single, dual (corrector plus potentiator), and triple therapies (two different correctors plus one potentiator).

Study characteristics

The authors included 19 studies (2959 children and adults) lasting between 1 day and 24 weeks (with an extension of two studies up to 96 weeks). Eight studies (344 participants) compared monotherapy: 4PBA, CPX, lumacaftor, cavosonstat and FDL169) to placebo (dummy treatment containing no active medicine), six studies (1840 participants) compared dual therapy (lumacaftor-ivacaftor or tezacaftor-ivacaftor) to placebo. Five studies (775 participants) assessed triple therapy (elexacaftor-tezacaftor-ivacaftor or VX-659-tezacaftor-ivacaftor); only the combination with elexacaftor progressed beyond early studies. In 14 studies, participants had two copies of F508del, in two studies participants had one F508del variant and one different variant, while in three studies participants had either two copies of F508del or one copy of F508del and one different variant.

Key results

Monotherapy versus control

These studies did not report any deaths or clinically relevant improvements in QoL scores. There was insufficient evidence to show an effect on lung function. All studies reported side effects, but it is difficult to assess their relevance due to the range of effects and the small number of participants in the studies.

Dual therapy versus control

Neither the lumacaftor-ivacaftor or tezacaftor-ivacaftor studies in people with two copies of F508del reported any deaths and there were improvements in QoL and lung function. Pulmonary exacerbation (a flare-up of symptoms) rates were also lower. Neither combination therapy was linked to severe side effects, although people starting treatment with lumacaftor-ivacaftor experienced shortness of breath for one to two weeks, this usually stopped without further treatment. More concerningly, in longer studies some people taking lumacaftor-ivacaftor experienced a rise in blood pressure; two people (out of over 500) even stopped lumacaftor-ivacaftor treatment because of high blood pressure. These side effects were not reported for tezacaftor-ivacaftor. Tezacaftor-ivacaftor therapy has not yet been assessed in children with CF under 12 years old.

Triple therapy versus control

No deaths were reported in the three studies. Triple therapies improved QoL scores and lung function, with no difference in the number or severity of side effects; there was a longer time until the next pulmonary exacerbation. There is high-quality evidence that elexacaftor-tezacaftor-ivacaftor therapy is clinically effective with few side effects for pwCF with one or two F508del variants aged 12 years or older. Further RCTs are required in children (under 12 years) and those with more severe respiratory function. The side effect profile of elexacaftor-tezacaftor-ivacaftor therapy seems to be similar to tezacaftor-ivacaftor, but we need to collect information over the longer term.

Quality of the evidence

The overall quality of the evidence varied from low to high. There were generally few details about study design, so we could not make clear judgements on potential biases. We had fewer concerns with the larger more recent studies. In 10 studies, some results were not analysed or reported. Some findings were based on studies that were too small to show important effects and for nine studies the results may not be applicable to all pwCF due to the age (i.e. only adults or only children studied) or an unusual design (pwCF received monotherapy and then combination therapy).

Thursday, December 17, 2020

Behind the Numbers Podcasts speaks to Dr. Stevens from Cochrane Canada

Mon, 12/14/2020 - 17:46

Behind The Numbers is a podcast aimed at disseminating research, news, & educational resources pertaining to Epidemiology and Biostatistics. Led by Gabriele Zitikyte, MSc Epidemiology student and executive member of the Canadian Society of Epidemiology and Biostatistics (CSEB)-uOttawa chapter, the podcasts  feature interviews and discussions that highlight different areas within epidemiology.

Recently, they spoke to Dr. Adrienne Stevens, the Managing Director of Cochrane Canada. Dr. Stevens expands on the differences between rapid reviews and systematic reviews, as well as the many ways that Cochrane is doing its part in combatting COVID-19 by continuing to promote evidence-informed health decision making. Dr. Stevens covers the Cochrane work on rapid review methodology to other Cochrane COVID-10 projects, such as the COVID-19 Recommendations Map.

Monday, December 14, 2020

Join us - Join in - Make a difference

Mon, 12/14/2020 - 13:40

The Membership team in Cochrane's People Services Department are delighted to announce a new version of our Join Cochrane pages that lay out all the varied ways people can get involved with Cochrane’s work. At the heart of the new content are:

The pages also showcase the fantastic Membership badges, which are available for to download from the Cochrane Account portal.

This week, the total number of Cochrane Members and Supporters hit the 100,000 mark. This impressive figure reflects the fact that we encourage anyone interested in our work to create a Cochrane Account, which unlocks access to free resources such as Cochrane Evidence Essentials and opportunities to contribute as part of Cochrane Crowd, the Cochrane Consumer Network, or on our volunteer hub, Cochrane TaskExchange.

Many of those who join as Supporters, will progress to earn Membership. Testimonies from Cochrane Members who share their experiences of getting involved, show the real value of Cochrane Membership as a reward for contributing to our work.

Thanks to our amazing translation teams, most of whom are volunteers, these pages are available in different languages - and the translators will have earned Membership points for their hard work!

We would like to thank the Web Team, and the Knowledge Translation Department, for their help in preparing these pages and their translated versions.

Monday, December 14, 2020

Anti-IL5 therapies for chronic obstructive pulmonary disease

Mon, 12/14/2020 - 12:35
In this short interview, author Iain Crossingham, Consultant Intensivist and Respiratory Physician, tells us more about this review and the treatment of airways diseases.

Tell us about this Cochrane Review
This is an interesting time for the treatment of airways diseases. Traditionally we've thought of these as coming under two main headings, asthma and chronic obstructive pulmonary disease (COPD), plus a handful of other rarer conditions such as bronchiectasis. Characteristically asthma caused variation in lung function tests such as peak flow or FEV1, either over time or with medication whereas COPD is defined by lung function that didn't improve ("fixed airflow obstruction"). Basing diagnosis on one dimension of the disease process (how quickly someone come blow air out of their lungs) obviously misses many other aspects of these conditions including the symptoms that impact people on a day to day basis.
 
In the clinic, we come across many different disease traits, for example

  • Wheeze/airflow obstruction
  • Cough, either daytime or disturbing sleep overnight
  • Sputum production, either intermittent or continuous
  • Frequent "exacerbations" or flare ups of symptoms
  • Structural changes in the lungs seen on CT scans
  • Persistent breathlessness and exercise intolerance
  • Association of symptoms with exposures at work or elsewhere

Why was it important to do this systematic review?
People may experience any of these and other traits regardless of whether their "official" label is asthma or COPD (or something else). Identifying the traits present in a particular individual at a particular time is what the pragmatic physician does to help agree a personalised treatment plan with an individual patient. This presents a problem for someone trying to be "evidence based" as trials have mostly lumped participants into broad but heterogenous groups based on diagnostic labels.



Why is this review important for people living with COPD and the clinicians treating them?
We've tried in this review to look at what are considered "asthma" treatments (anti IL5 drugs) in individuals with COPD who nonetheless may have traits that might respond to these drugs. We'd planned specific subgroup analyses looking at those with raised levels of particular biomarkers such as peripheral blood eosinophil counts that might define certain traits. The included trials were somewhat of a disappointment, mostly taking all comers rather than targeting groups who theoretically might respond. These were "lumper" trials, looking for(and on the whole failing to find) a modest benefit in a whole population. As you might have gathered, I think we need to split these groups down and personalise our treatments.  
 
What can people living with COPD and clinicians treating them take from this evidence?
Should people living with COPD or their clinicians be racing to start anti-IL5 drugs? No. However this is hopefully just a start. In the future, I'd like to see a person with an airways disease (be it labelled asthma or COPD) be able to choose the evidence based treatments that work for their particular set of problems and avoid the therapies that aren't relevant to their manifesting disease traits. There is clearly a challenge to us systematic reviewers. How do we collect evidence when the diagnostic labels used in trials don't capture the breadth of the experience of those living with the conditions?

Monday, December 14, 2020

COVID-19 Recommendations Map: Turning evidence into policy and practice

Mon, 12/14/2020 - 10:50

Today, the COVID-19 Recommendations Map launches, offering policymakers, healthcare practitioners, researchers and the general public - anywhere in the world - a comprehensive catalogue of critically appraised evidence.

This global collaborative effort from Cochrane Canada, McMaster University’s WHO Collaborating Centre for Infectious Diseases and an international consortium of researchers spanning six continents have developed this living map of the latest evidence-based recommendations for the prevention and care of COVID-19.

The project brought together Cochrane groups from across the world including Cochrane Germany, Cochrane Canada, Cochrane South Africa, and Cochrane Iberoamerica.

“The fast-evolving COVID-19 pandemic has thrown up the challenge of rapidly developing, appraising, disseminating and updating multiple guidelines. To meet this challenge, the international team we have assembled will provide evidence-based recommendations that can be accessed by anyone and applied in virtually any setting across the globe.”

Supporting healthcare decision-making in Canada and around the world, especially when time is of the essence, is the primary goal of Cochrane Canada and its many partners on this project, said Cochrane Canada’s Managing Director, Dr. Adrienne Stevens.

“Collectively, we have mobilized quickly to get this work underway. Our hope is that by providing access to these recommendations and their underlying evidence, we are reducing waste in research by capitalizing on efforts already put forth. Knowing what exists can also help inform decisions on what additional guidelines should be undertaken, effectively steering the use of research dollars on COVID-19.”

Funding for the living map was provided by the Canadian Institutes of Health Research (CIHR).

Monday, December 14, 2020

Cochrane US vs. COVID-19: Sharing US evidence in a free online repository

Fri, 12/11/2020 - 16:35

Members of the public, health professionals and researchers know that there is ‘information overload’ about the COVID-19 pandemic, with lots of mistrust and misinformation. Cochrane US wanted to help people find trustworthy evidence about COVID-19 in the US by leveraging the strengths of the members of the new US Network.



Cochrane US created a comprehensive online repository to share COVID-19 research, projects and guidelines from trustworthy sources. This is a living resource that they add to and update in real-time and offer free on their website. They also included videos about systematic reviews, Plain Language Summaries of evidence, and other easy-to-understand resources.

Read more about the work that Cochrane US did to address information needs during the COVID-19 pandemic in this short case story.

Friday, December 11, 2020

Cochrane Portugal vs. COVID-19: Sharing high quality evidence in newsletters

Thu, 12/10/2020 - 20:49

Research about COVID-19 is growing fast during the pandemic. Healthcare professionals, journalists, policy-makers and people with an interest wanted simple summaries of the latest evidence in Portuguese to help inform their decisions.

To meet this need, Cochrane Portugal produced regular newsletters in the Portuguese language. They included short summaries about new COVID-19 research from around the world and shared the newsletters through their mailing list and on their website.

People are busy so they made sure that every newsletter was not longer than one page and took less than seven minutes to read. They focused on high-quality studies that were relevant in clinical practice and wrote the newsletters in a non-technical way so they could be used by people who were not doctors. Newsletters were sent out twice a week.

To learn more about the what Cochrane Portugal learned in this process in this short case study. 

 Cochrane Portugal received funding from the Institute for Evidence Based Healthcare at the University of Lisbon School of Medicine.

Thursday, December 10, 2020

COVID‐19: working together and making a difference for decision‐makers

Thu, 12/10/2020 - 17:15

Published on the Cochrane Library is a new editorial, 'COVID‐19: working together and making a difference for decision‐makers'. The editorial outlines Cochrane's agile response to the situation and the many lessons learned.

It also introduces the special supplement to the 'Collaborating in response to COVID‐19: editorial and methods initiatives across Cochrane.' The The supplement collects examples of initiatives for coordinating and preparing for evidence synthesis, facilitating and developing methods for evidence synthesis, organizing collaborative approaches for evidence synthesis and publication, and ensuring evidence informs guidelines and practice.

 

Thursday, December 10, 2020

Cochrane publishes two COVID-19 scoping reviews to inform WHO guidance

Thu, 12/10/2020 - 10:46

Cochrane has expanded its response to COVID-19 by publishing two rapid scoping reviews about care bundles in the intensive care unit (ICU) and measures implemented in schools to contain the SARS-CoV-2 virus. Both reviews were commissioned by the World Health Organisation to inform their guidance. The reviews serve as exemplars for how similar research could be published by Cochrane beyond the pandemic.

Cochrane does not ordinarily publish scoping reviews, which differ from systematic reviews in important ways. Rather than summarise the results of studies to assess the effect of an intervention or accuracy of a diagnostic test, the purpose of a scoping review is to identify the amount and type of evidence relating to a given topic. Scoping reviews can play an important role for researchers and decision makers by mapping and characterizing an evidence base to highlight gaps or inform the design of a further systematic review.

Scoping reviews follow many of the same steps of a systematic review including pre-specification of methods, and a systematic approach to identify, sift and present the evidence. They generally have a broader scope than a systematic review and, given that the objective is not to assess effectiveness or safety, there is usually no critical appraisal of studies, synthesis of their outcome data, or application of established GRADE methods.

The reviews followed a set of interim recommendations set by the Cochrane Editorial and Methods Department (EMD), which were based on existing conduct and reporting standards and guidance.[refs 1,2,3] Areas for development have been highlighted that would be needed to ensure quality and consistency on a wider scale, but the reviews serve as an important proof of concept that we hope to build upon in the future to continue meeting the diverse needs of stakeholders.

Declan Devane, Director of Cochrane Ireland and one of the authors of the ICU care bundles scoping review commented “I think it critical that Cochrane respond to the evidence synthesis needs of health decision makers. Like much of the recent COVID-19 evidence response, this scoping review was only possible in the time available because of the commitment of a team of clinicians and methodologists who were supported flexibly and iteratively by Cochrane. Processes were adapted and flexed to meet commissioners needs resulting in a good experience for all concerned. The learning from our experience will help inform future scoping review processes. I believe firmly that the relevance and value of Cochrane will depend on its ability to respond innovatively, and promptly, to decision-maker needs. This is another example that shows we can.”


A range of initiatives are underway to reflect on what has been achieved by the Cochrane community during the pandemic, including the Cochrane COVID-19 supplement that published this week. The Central Executive Team is considering whether and how new review and article types should be pursued beyond the pandemic situation to meet user needs and accommodate innovation in evidence synthesis. A web-based survey will be circulated in January to invite Cochrane staff and members to share their views.

Tuesday, December 22, 2020

Featured Review: What types of interventions benefit people experiencing homelessness to quit smoking?

Thu, 12/10/2020 - 10:31
Interventions to reduce tobacco use in people experiencing homelessness

Background
People experiencing homelessness are more likely to use tobacco, and face many problems that make it difficult for them to quit. Health problems caused by using tobacco are among the leading causes of death among this group of people, so there is a need to find new ways to reduce tobacco use in people experiencing homelessness. Healthcare guidance says that treatment to quit tobacco smoking should include some form of counseling or support, plus medicines designed to help people stop smoking. However, this treatment is often not provided or used among people experiencing homelessness. This review looked at whether systems designed to help adults experiencing homelessness to get treatments to quit tobacco, and treatments designed to help adults experiencing homelessness to quit tobacco lead to more use of treatments and more people quitting tobacco use. The authors also looked at whether treatments to help adults experiencing homelessness to quit tobacco changed their use of other drugs and their mental health

The study included 10 studies involving 1634 participants. One of these studies is still being carried out, but the other nine have been completed. All participants were tobacco smokers, aged 18 years or older, and had experienced homelessness. Most participants were recruited from places within the community, such as homeless shelters, but some were also recruited from healthcare clinics. All studies offered participants some form of counseling support to quit smoking, and eight of these studies also offered stop‐smoking medicines. The treatments tested in the included studies were: e‐cigarettes, text‐message support, rewards for stopping smoking, more intensive counseling support, treatments focused on other lifestyle challenges plus smoking, and cognitive behavioral therapy. The evidence is up to date to January 2020.



Key results
There was not enough information to decide whether stop‐smoking treatments targeted specifically at people experiencing homelessness made them more likely to quit smoking than standard treatment to stop smoking. There was also not enough information to determine whether these treatments affected the mental health or drug use of people experiencing homelessness.

Quality of evidence
The authors judged all of the information included in this review to be either of low or of very low quality. This is because the studies included in this review were small, and there were problems with how some of the included studies were carried out. This means it is difficult to know whether these interventions help people who experience homelessness to quit smoking. The findings of this review are very likely to change as new studies are completed.

Thursday, December 10, 2020

Featured Review: Antenatal corticosteroids for accelerating fetal lung maturation in women at risk of preterm birth

Thu, 12/10/2020 - 10:06

The Cochrane review about antenatal steroids in reducing risk of infant mortality and morbidity is an important one in Cochrane's history. Cochrane's logo is based on the forest plot from the original publication in 1982. This review has recently been updated and lead author, Fiona Stewart, tells us how the logo might look now, base on the current data.

What does this update tell us? 
Our overall findings can be summed up like this: antenatal steroids given to women at risk of preterm birth reduce the risk of infant mortality and morbidity. In other words, babies are more likely to survive and less likely to have serious illness, such as respiratory distress syndrome and intraventricular haemorrhage (bleeding in the brain). The evidence also suggests that there is probably little risk of death or infection in the mothers who receive the steroids. 

What is different to the last version? 
In the last version of the review, the authors identified a distinct lack of evidence from low- and middle-resource countries. Since then the World Health Organisation has organised two large randomised controlled trials to address precisely this gap and one of those trials is now included in this latest update. This means we now have a much better idea of the benefits and risks of antenatal corticosteroids in a wide range of settings where there are different levels of healthcare service provision.

Another important difference from the last version is that we have taken into account the trustworthiness of the evidence, in addition to the standard methods that we use to assess risk of bias and to rate the overall certainty of evidence. We used a set of criteria, developed by the Cochrane Pregnancy and Childbirth group, to assess whether each trial in the review can demonstrate its trustworthiness in terms of research governance and feasibility of results. Where we had concerns about a trial’s trustworthiness we contacted the study authors for further information. Where our concerns were not resolved or where we did not receive any response, we did not include those trials in our analysis. 

 

The Cochrane logo is based on the forest plot of the first publication of this review. Each horizontal line represents the results of one study, while the diamond represents the combined result - our best estimate of whether the treatment is effective or harmful. The diamond sits clearly to the left of the vertical line representing “no difference”; therefore the evidence indicates that the treatment is beneficial. Would this update to the review change the forest plot that the logo is based on? 
The Cochrane logo represents what the forest plot would have looked like in 1982, had a meta-analysis been carried out using the trial evidence that was available at the time for the outcome of neonatal mortality.  Now, decades later, we have substantially more evidence and if the logo was created from scratch now we wouldn’t be able to fit enough horizontal lines in it to illustrate the number of trials we now have included in the analysis! Most importantly, the diamond at the bottom would still be in the same place because the analysis in the logo and the analysis in our update both show that antenatal steroids reduce the risk of neonatal death compared to placebo or no treatment. 

What can clinicians/and or mothers take from this evidence? 
Clinicians and mothers can be confident that there is high-certainty evidence to support the use of antenatal steroids for women at risk of preterm birth, no matter where you are in the world since the evidence is consistent across high-, middle- and lower-resource settings. The evidence also demonstrated that giving antenatal steroids to mum is safe and does not result in any long-term harm to their babies. However it is important that they are only given to women considered at high risk of preterm birth because appropriate timing is very important to ensure maximum benefit. 

Will this review be updated again?
Yes, the review will be updated to include the results of trials that are still ongoing. There are still a few remaining questions; firstly, whether antenatal steroids have the same benefits in different gestational age ranges. The majority of the evidence in the review comes from trials where the women were very preterm (approximately 28-34 weeks). We would like to know if the effect of corticosteroids compared with placebo is similar at the later preterm period (approximately 34-36 weeks). We know of at least one large trial – ACTION-II, organised by the WHO – which is investigating antenatal corticosteroids compared with placebo in women at 34-36 weeks. We anticipate being able to include the results from that trial, and four smaller trials that are ongoing, in another update in a year or so. Secondly, we are interested in the effects of antenatal steroids in particular groups for whom there is currently limited evidence; for instance, women with medical problems in pregnancy such as diabetes, or women who are carrying more than one child.

Wearing Cochrane evidence: a personal story of impact
Rebecca Selby, a mum of four, shares how this Cochrane Review has impacted her family.

Tuesday, December 29, 2020

Featured Review: Tourniquet in knee replacement surgery

Tue, 12/08/2020 - 17:04

New Cochrane Systematic Review shows that knee replacement surgery using a tourniquet increases the risk of serious complications, and causes additional pain after surgery

What are the benefits and risks of using a tourniquet in knee replacement surgery?
Senior author Mr Peter Wall, Consultant Orthopaedic Surgeon from Warwick Clinical Trials Unit and University Hospitals Coventry and Warwickshire NHS Trust, summarized:

The evidence indicates that knee replacement surgery performed with a tourniquet increases the risk of serious complications needing additional healthcare, many of which might be avoided if a tourniquet is not used. Most people do very well after knee replacement, but like any major surgery, there are risks and use of a tourniquet may exacerbate these.

Why is this question important?
Knee replacement is a common operation that involves replacing a damaged, worn, or diseased knee with an artificial joint made of metal and plastic. Most surgeons prefer to carry out knee replacement surgery with the aid of a tourniquet ‐ a tight band placed around the thigh that restricts blood flow to the knee. Potential benefits of using a tourniquet include limiting blood loss during surgery and making it easier to conduct the operation. However, a tourniquet may increase the risk of pain and complications for patients after surgery. 

How did the authors identify and evaluate the evidence?
First, they searched for relevant, robust studies in the medical literature. They then compared the results and summarised the evidence from all studies. Finally, they assessed how certain the evidence was. To do this, they considered factors such as the way studies were conducted, study size, and consistency of findings across studies. Based on these assessments, they categorised the evidence as being of very low, low, moderate, or high certainty.

What did they find?
They found 41 studies that involved 2819 people (944 men and 1777 women) who were randomly assigned to have surgery with a tourniquet, or surgery without. This type of study, known as a randomised controlled trial, provides the most robust evidence about the effects of a treatment.

Studies were conducted in hospitals in Australia, Asia, Europe, and the USA. Each study involved between 20 and 166 people who were between 58 and 84 years of age. They were followed for between one day and two years after surgery.

Five studies were publicly funded, and one study received funding from a medical equipment manufacturing company. The other 35 studies did not receive specific funding or did not state who funded them.

The studies provided low to moderate evidence that:

  • Pain on the first day after surgery is probably worse with a tourniquet. On average, on a scale of 0 to 10 (higher scores = worse pain), people operated on with a tourniquet rated their pain as 5.81. People operated on without a tourniquet rated their pain as 4.56 (average difference: 1.25 points);
  • Knee function one year after surgery is probably similar with or without a tourniquet. On average, on a scale of 0 to 100 (higher scores = better functioning), people operated on with a tourniquet rated their knee function as 89.74. People operated on without a tourniquet rated their knee function as 90.03 (average difference: 0.29 points);
  • Satisfaction with treatment may be similar with or without a tourniquet. Six months after the operation, 94% of people operated on with or without a tourniquet were 'extremely' or 'very' satisfied with their treatment;
  • There may be little or no difference in health‐related quality of life with or without a tourniquet. On average, on a scale of 0 to 100 (higher scores = better quality of life), people operated on with a tourniquet rated their quality of life as 54.64. People who had surgery without a tourniquet rated their quality of life as 56.17 (average difference: 1.53 points); and
  • Serious adverse events such as blood clots in the leg or lung, infection, or re‐operation other than to replace the artificial joint are probably more likely to occur with a tourniquet. Five per cent of people operated on with a tourniquet reported serious adverse events compared to 2.9% of people operated on without a tourniquet.

We do not know if using a tourniquet affects chances of needing a second operation to replace an artificial joint because available evidence is of very low certainty.

No studies investigated the effects of surgery with a tourniquet on people’s ability to process thoughts (cognitive function).

What does this mean?
Knee replacement with a tourniquet is probably slightly less beneficial, and is associated with greater risks, than surgery without a tourniquet.

How up‐to‐date is this review?
Evidence in this Cochrane Review is current to March 2020.

Wednesday, December 9, 2020

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